CIRQLE

 

 

CURRENT RESEARCH

Solving the Question of Inflammation or Sepsis Hastily–Serial Management Study

Timecourse study with serial measurements to examine correlation between test results and patient trajectory. Currently enrolling in conjunction with Cytovale.
Solving the Question of Inflammation or Sepsis Hastily–Integration into the ER

Pragmatic use study to determine how and when the ED will order ISI with subsequent decisional impacts. Currently enrolling in conjunction with Cytovale.
Accelerating COVID-19 Therapeutic Interventions and Vaccines–4

Comparing the effectiveness of antithrombotic strategies for prevention of adverse outcomes in hospitalized patients with COVID-19. Currently enrolling in conjunction with the NIH under the umbrella of NECTAR.
Pragmatic Trial Examining Oxygenation Prior to Intubation

Understanding the impact of preoxygenation modes prior to intubation. Currently enrolling in conjunction with the Pragmatic Critical Care Research Group.
A Prospective Cohort to Assess Performance of Video Oximetry

Confirming the accuracy of video oximetry compared to pulse oximetry and blood gas analysis. Currently enrolling in conjunction with the University of South Australia.
Johns Hopkins Activity and Mobility Promotion

Improving patient outcomes through early and systematic activity and mobility. Currently enrolling in Phase 2 in conjunction with Johns Hopkins University.
Pritelivir Versus Foscarnet for the Treatment of Acyclovir-resistant Mucocutaneous HSV Infections in Immunocompromised Subjects

Phase 3 study evaluating effectiveness of pritelivir for treatment of HSV infections. Currently enrolling in conjunction with AiCuris.
Longitudinal Study of Undergraduate Baseball Pitchers

Assess for MRI and exam findings as risk factors for dominant shoulder and/or elbow injuries of elite college pitchers. Observational study in conjunction with LSU Sports Medicine.

 

 

cirqle_partners

 

 

 

PAST PROJECTS

 

SQuISH

Solving the Question of Inflammation versus Sepsis Hastily — Attempting to develop a point-of-care diagnostic test that can be performed quickly at the initial suspicion of sepsis

O'Neal HR Jr, Sheybani R, Caffery TS, Hamer D, Laperouse LM Jr, Musso MW, O'Neal CS, Tse HTK, Shah AM, Thomas CB. Assessment of a cellular host response test to risk-stratify suspected COVID-19 patients in the emergency department setting. PLoS ONE 2022; 17(3): e0264220.

O’Neal HR Jr, Sheybani R, Caffery TS, Musso MW, Hamer D, Alwood SM, Berlinger MS, Jagneaux T, LaVie KW, O’Neal CS, Sanchez MA, Walker MK, Shah AM, Tse HTK, Thomas CB. Assessment of a cellular host response test as a sepsis diagnostic for a suspected infection population in the emergency department setting. Crit Care Exp 2021; 3(6): e0460.

Guillou L, Sheybani R, Jensen AE, Di Carlo D, Caffery TS, Thomas CB, Shah AM, Tse HTK, O'Neal HR Jr. Development and validation of a cellular host response test as an early diagnostic for sepsis. PLoS ONE 2021; 16(4): e0246980.

 

 

MENDS2

Maximizing the Efficacy of Sedation and Reducing Neurological Dysfunction and Mortality in Septic Patients with Acute Respiratory Failure

Hughes CG, Mailloux P, Devlin JW, Swan JT, Sanders RD, Anzueto A, Jackson JC, Hoskins AS, Pun BT, Orun OM, Raman R, Stollings JL, Kiehl AL, Duprey MS, Bui LN, O'Neal HR Jr, Snyder A, Gropper M, Guntupalli K, Stashenko G, Mayur B, Patel MB, Brummel NE, Girard TD, Dittus RS, Bernard GR, Ely EW, et al for the Maximizing the Efficacy of Sedation and Reducing Neurological Dysfunction and Mortality in Septic Patients with Acute Respiratory Failure (MENDS2) Study Investigators. Dexmedetomidine or propofol for sedation in mechanically ventilated adults with sepsis. N Engl J Med 2021; 384(15): 1424.

 

 

PassITON

Passive Immunity Trial for Our Nation

Self WH, Wheeler AP, Stewart TG, Schrager H, Mallada J, Thomas CB, Cataldo VD, O'Neal HR Jr, Shapiro NI, Higgins C, Ginde AA, Chauhan L, Johnson NJ, Henning DJ, Jaiswal SJ, Mammen MJ, Harris ES, Pannu SR, Laguio-Vila M, El Atrouni W, de Wit M, Hoda D, Cohn CS, McWilliams C, Shanholtz C, Jones AE, Raval JS, Mucha S, Ipe TS, Qiao X, Schrantz SJ, Shenoy A, Fremont RD, Brady EJ, Carnahan RH, Chappell JD, Crowe JE Jr, Denison MR, Gilchuk P, Stevens LJ, Sutton RE, Thomsen I, Yoder SM, Bistran-Hall AJ, Casey JD, Lindsell CJ, Wang L, Pulley JM, Rhoads JP, Bernard GR, Rice TW for the Passive Immunity Trial for Our Nation (PassITON) Investigators. Neutralizing COVID-19 Convalescent Plasma in Adults Hospitalized with COVID-19. Chest 2022; Published June 30 ahead of print.

Self WH, Stewart TG, Wheeler AP, El Atrouni W, Bistran-Hall AJ, Casey JD, Cataldo VD, Chappell JD, Cohn CS, Collins JB, Denison MR, de Wit M, Dixon SL, Duggal A, Edwards TL, Fontaine MJ, Ginde AA, Harkins MS, Harrington T, Harris ES, Hoda D, Ipe TS, Jaiswal SJ, Johnson NJ, Jones AE, Laguio-Vila M, Lindsell CJ, Mallada J, Mammen MJ, Metcalf RA, Middleton EA, Mucha S, O'Neal HR Jr, Pannu SR, Pulley JM, Qiao X, Raval JS, Rhoads JP, Schrager H, Shanholtz C, Shapiro NI, Schrantz SJ, Thomsen I, Vermillion KK, Bernard GR, Rice TW for the Passive Immunity Trial for Our Nation (PassITON) Investigators. Passive Immunity Trial for Our Nation (PassITON): study protocol for a randomized placebo-control clinical trial evaluating COVID-19 convalescent plasma in hospitalized adults. Trials 2021; 22(1): 221.

 

 

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